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Introduction to Human Anatomy

Homeostasis and Feedback

Explain negative feedback and distinguish it from positive feedback.

Stability is an active process

Your surroundings change, meals arrive irregularly and muscles use different amounts of energy, yet cells need reasonably stable conditions. is the regulation that keeps internal variables within suitable ranges. These variables include temperature, blood glucose and aspects of fluid composition. Stability does not mean a perfectly unchanging number: values fluctuate with activity, time of day and other circumstances. A regulated range is more like maintaining a comfortable room temperature than freezing the room at a mathematically exact value. The body continually measures conditions and adjusts its responses.

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Homeostasis and Feedback

Homeostasis and Feedback. Disturbance: A regulated variable changes.. Sensor and control: Information is detected and integrated.. Effector response: Activity changes to influence the variable.. Negative feedback: The response reduces the original disturbance.Open diagram larger ↗
Original educational schematic: Homeostasis keeps internal conditions within workable ranges through regulated responses.

Negative feedback opposes change

A typical control loop includes a sensor, a control centre and an . Sensors detect a variable; the control centre compares information with a desired condition; effectors change their activity. If body temperature rises, responses such as increased skin blood flow and sweating can increase heat loss. As temperature moves back towards its range, the driving signal decreases. This is because the response opposes the original disturbance. The word negative describes the relationship, not a harmful effect. Many overlapping loops cooperate rather than relying on one simple thermostat.

Positive feedback amplifies change

reinforces a developing process until an external limit or endpoint stops it. During childbirth, cervical stretch can promote oxytocin release, which strengthens contractions and produces more stretch. Delivery removes the stimulus. Positive feedback is useful when a process needs to move decisively towards completion, but uncontrolled amplification can be dangerous. Not every bodily response is homeostatic, and a response can maintain one variable at a cost to another. Understanding the loop requires identifying what is sensed, what changes and how the response affects the initial stimulus. This is more useful than memorising the words positive and negative.

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Key terms

Homeostasis
Regulation of internal conditions within ranges compatible with function.
Negative feedback
A response that opposes the change that triggered it.
Positive feedback
A response that amplifies the change that triggered it.
Effector
A cell, tissue or organ that carries out a response.
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Sources & further reading

Original MyAnatomy explanation and schematic · Source review: 26 October 2026 · Foundational education. See editorial standards and review limits.

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